![]() ![]() ![]() ![]() SARS-CoV-2–specific T cells were not detectable in the nasal turbinates, salivary glands, and tonsils on day 10 after infection. ![]() Virus-specific effector CD8 + and CD4 + T cells became detectable in the BAL and lung tissue on days 7 to 10 after viral RNA, radiologic evidence of lung inflammation, and IFN-activated myeloid cells had substantially declined. 18F-fluorodeoxyglucose ( 18FDG)–avid lung abnormalities and interferon (IFN)–activated monocytes and macrophages in the bronchoalveolar lavage (BAL) were found on days 3 to 4 after infection. Viral RNA levels were highest on days 1 to 2 after infection and fell precipitously thereafter. Here, we used rhesus macaques to model protective primary immune responses in tissues during mild coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily replicates in mucosal sites, and more information is needed about immune responses in infected tissues. Barber +19 authors +17 authors +12 authors fewer Authors Info & Affiliations Johnson, Mario Roederer, Alan Sher, Daniela Weiskopf, Alessandro Sette, Emmie de Wit, Heather D. Lora, NIAID/DIR Tuberculosis Imaging Program, Kelsie Brooks, , E. Kauffman, , Shunsuke Sakai, Danielle E. Nelson, Sivaranjani Namasivayam, , Taylor W. ![]()
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